Hi Dan,
Thanks for the update. I have read this thread from the beginning - last time it has been active I had not found this forum yet.
I have read that, when you first have found this forum in 2012, niacin have been efficient for you. So I guess that after taking it daily for a while, it has stopped to be efficient.
I think also that those who have long term results with niacin take it only before O, and in small to moderate dose, and not on a daily basis, like to not "wear off" the effect of niacin ( I do the same with the supplements I take, I take them only before O, not on a daily basis, even if I am not taking niacin). Would it have some benefits for you if you take niacin only before O , in moderate dose ?
Also, like in my case, I think that even when we have found some supplements preventing most of the POIS symptoms, more than 1 to 2 Os a week on a regular basis is too much for a POIS sufferer and for any currently known method to prevent and control POIS symptoms. I read about your goal of an O every two days, but I do not think anyone have achieve this and not having POIS symptoms back in any way. Personally, at 1 O a week or every 5 days, it's usually ok with my current method.