Author Topic: Sjögren's syndrome  (Read 3795 times)

Muon

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Re: Sjögren's syndrome
« Reply #15 on: November 08, 2017, 10:33:31 AM »
Disaster,

Did they find clustered lymphocytes around your salivary glands and damage to the glands?

Disaster

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Re: Sjögren's syndrome
« Reply #16 on: November 08, 2017, 12:36:27 PM »
My lip biopsy was positive for Sjogren's

Muon

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Re: Sjögren's syndrome
« Reply #17 on: November 10, 2017, 12:59:14 PM »
I understand it was positive but did your doctor tell you any details?

Disaster

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Re: Sjögren's syndrome
« Reply #18 on: November 11, 2017, 10:49:36 PM »
The report says I have a Focus score of 1.0. And it says that score is equal to lymphocytes/50 cells. Something like that.

Muon

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Re: Sjögren's syndrome
« Reply #19 on: December 12, 2017, 01:28:42 PM »
Ok thanks, the focus score is all I need. This means you have infiltration of lymphocytes. IgG4-RD could play a role in this, that's why I was curious about it. This focus score could also fit IgG4 involvement. https://www.ncbi.nlm.nih.gov/pubmed/25100215

''IgG4-related disease (IgG4-RD), formerly known as IgG4-related systemic disease, is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4-secreting plasma cells'' https://en.wikipedia.org/wiki/IgG4-related_disease

Can you check out your IgG4 levels? I'm curious about this and may shed some light on POIS. You need an IgG4 test with a cut-off value above the upper reference limit of 135 mg/dl. IgG4 tests with high cut-off limits are hard to find. I have elevated IgG4 myself and wonder if more POIS patients got this as well.
« Last Edit: December 13, 2017, 08:51:05 AM by Muon »

Disaster

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Re: Sjögren's syndrome
« Reply #20 on: December 20, 2017, 07:40:52 AM »
I haven't been tested for IgG4 only IgG subclasses

Muon

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Re: Sjögren's syndrome
« Reply #21 on: December 20, 2017, 11:35:05 AM »
IgG 1-4 are the IgG subclasses. They have probably ruled this out then.

Disaster

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Re: Sjögren's syndrome
« Reply #22 on: December 20, 2017, 11:04:00 PM »
I have low IgG subclasses 1 and 3, normal 2 and 4.