Author Topic: A noticeable and important medication that had very good results for one week  (Read 957 times)

Muon

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Hello Nas,
Yes that's something that is on my mind, a generalized endothelial dysfunction. However involvement of mast cell activation is on top of my list though. Mast cells can regulate BBB permeability (just look up some papers). They also play a role in late phase allergic/hypersensitivity reactions and can modulate T-cell responses.

Hi Fernando,
You also see patients having connective tissue disorders in conjuction with mast cell activation and autonomic problems. The interaction of connective tissue and mast cells is also a line of research. Perhaps connective tissue mast cells are releasing mediators which weakens this tissue and lead to bad posture.

Mast Cells are found close to small blood vessels in loose connective tissue. They contain large secretory granules of heparin proteoglycan - a weak anticoagulant. They also contain histamine, which promotes an inflammatory reaction when secreted. Release of histamine causes endothelial cells lining venules to contract, weakening the junctions between these cells, and allowing proteins and cells from the plasma to leak through into the connective tissue.
https://histology.leeds.ac.uk/tissue_types/connective/connective_phagocytes.php

A New Disease Cluster: Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome, and Ehlers-Danlos Syndrome
https://www.jacionline.org/article/S0091-6749(14)02927-3/abstract

https://www.karger.com/Article/Pdf/233760

I personally have problems with my tendons during POIS episodes including the heel and groin area for example. Perhaps mast cells are being activated and interact with connective tissue. But I wonder if an endothelial dysfunction can weaken the junction between these endothelial cells without the need of histamine/mediator release.

Nas

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I personally have problems with my tendons during POIS episodes including the heel and groin area for example. Perhaps mast cells are being activated and interact with connective tissue. But I wonder if an endothelial dysfunction can weaken the junction between these endothelial cells without the need of histamine/mediator release.

That's what's on my mind right now Muon;
Perhaps we have a general endothelial dysfunction caused by lack of Choline/Acetylcholine nutrients. I have yet to try a successful Choline type treatment, I do remember Sam-e being beneficial, but that could explain the success others have with this type of treatment.

Nas

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Hi everyone,
So I just tried Orgasm on 60mg Mestenon; I took 60 mg at ~5pm then I took another another tablet at 7:30pm just in case, because Mestenon has a 3 hours range of effectiveness. I also want to add that I already took Mestenon 60mg yesterday and the day before.

Anyways at Orgasm I didn't feel much symptoms but at about 30 minutes symptoms started to pile and become very severe. At the start I didn't think I had symptoms but they slowly piled up to be heavy nausea, brainfog, disconnection and speech problems. On the speech problems at like 10 minutes I barely felt a problem saying anything but as time passed and I kept talking I started noticing a growing difficulty.

Overall though, orgasm usually cripples me into a zombie like state where I can barely say anything or think of anything. This time however, while still symptoms crept slowly afterwards, I feel like I'm not completely crippled. It was kinda similiar in a way to my Sam-e experience but this time I guess it was a much more noticeable of a difference.
I'll update you on my state tomorrow and see how my situation goes.

I am hoping that the effectiveness grows with the contiuous use of Mestenon. Overall the symptoms are decreased about 30 % which is unfortunately not as successful as emornazim's and scrub's.
« Last Edit: June 17, 2018, 01:29:13 PM by Nas »

Quantum

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I am hoping that the effectiveness grows with the contiuous use of Mestenon. Overall the symptoms are decreased about 30 %.

I am glad to hear this, Nas.  You often shared that you have found absolutely nothing so far to relieve your POIS, but not true anymore.  You seem to respond to cholinergic support.   It may be now a question of refining your method ( dosage, timing of dose, cholinergic add on like lecithin, etc....)

Good luck in refining your method.   30% is already much better than nothing, though.
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

Scrub

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Hi everyone,
So I just tried Orgasm on 60mg Mestenon; I took 60 mg at ~5pm then I took another another tablet at 7:30pm just in case, because Mestenon has a 3 hours range of effectiveness. I also want to add that I already took Mestenon 60mg yesterday and the day before.

Anyways at Orgasm I didn't feel much symptoms but at about 30 minutes symptoms started to pile and become very severe. At the start I didn't think I had symptoms but they slowly piled up to be heavy nausea, brainfog, disconnection and speech problems. On the speech problems at like 10 minutes I barely felt a problem saying anything but as time passed and I kept talking I started noticing a growing difficulty.

Overall though, orgasm usually cripples me into a zombie like state where I can barely say anything or think of anything. This time however, while still symptoms crept slowly afterwards, I feel like I'm not completely crippled. It was kinda similiar in a way to my Sam-e experience but this time I guess it was a much more noticeable of a difference.
I'll update you on my state tomorrow and see how my situation goes.

I am hoping that the effectiveness grows with the contiuous use of Mestenon. Overall the symptoms are decreased about 30 % which is unfortunately not as successful as emornazim's and scrub's.

Have you tried any other cholinesterase inhibitors? I had success with Pyridostigmine, but i'm very curious about taking Donepezil or Galantamine, especially Donepezil because it's half life is very long.

Nas

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I am hoping that the effectiveness grows with the contiuous use of Mestenon. Overall the symptoms are decreased about 30 %.

Good luck in refining your method.   30% is already much better than nothing, though.

Thank you Quantum and yes Mestenon is definitely the way forward but I feel like it's not enough. I feel like I need more medications to treat different things like inflammation or better way to keep the dosage high enough.

Nas

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No scrub, I haven't but I'll probably try donepezil and see how effective it is.

emirnazim

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Hello everyone

I saw all your replyes. Some of you had asked me some questions . Excuse me for my being late . I only want to make an update of my last situation .and will reply on every message ASAP.

Its 45 day  lasts from the time i have took mestioNon. After that day i wrote each days details in order to make sure if what is the main cause .  I tried so many experiments . The first sign may be is my 45 day invisible state on this pois forum . But dont know whether is it good nor not . During these 45 day . I took so many dietry supplemenet as below . I took mestinon then to make sure if was it really beneficial for me , i stoped taking mestionon for near 15 days then started to take again . In this period i took also    B6.- B12 -Fish oil -lecithin- C vit - egg daily one - garlic one glove per day - and cut out the whole cymbala or doluxetine .even i wrote the taking hour and details of these medication , i can not analyze the total information and come to result. But l will try to be more real and accur.

1- mestinon really is working to me ... I mean i can sense the effects of its existence in my body . Specially for cutting down the need for much sleep . Specially for being motivated automatically.specially for increasing the strangh of my muscles .and getting tired not as soon as past time . When i see that POTS syndrome sufferes can not stand in their feet more then one minute , because of their increasing heart rates, i can not say that i had pots syndrom .because when i stand up i dont get faint or much heart rates like 140 130 120 .but i do know that when i stand up my heart is suffering from falling into hard situation .by taking mestinon many signs of that situation weared off. I can now run or walk at fast rates and get not asthma like state as hard as before . One of the other i portant symptoms of pois is high irritability . I think mestinon couldnt help with this but B6 or B12 does . I mean i can feel that after taking b6 and b12 my irritability will wear off . Go off. I think taking one egg and garlic and fish oil have positive effects too . So 7 days ago i stoped mestioNon again and took lecithin two time .1200 mg per each time . I cAn say that taking two of lecithine made me feel good too .like mestinon ' lecithin can help me in the same way .i m of the opinion that i have cholin related problem . But i need taking it every time every day not only after orgasm or befor orgasm . I have not tested for anti ach receptor blood test . I had not droped eye like MG sufferes have .i think the test will come back negative .but dont know why mestinon can help me positively. I ordered hupersine A too .not take yet .but will report the results . I am not familiar with anticholinerase drugs . It will be good if someone helpme to find out the best chois

Very important note :my orgasm rate has increased very much related to the past . I have 3 to 4 time per week Orgasm in average and have no flu like symptom s. Irritability and change in sound or voice of me is the biggest ana noticable symptoms after O


For example we have ;

Mestinon -mytelase-huperzine a -cholin suppliment -lecithin-alpha gpc - ..alpha cbg or so on ...

But dont know which will be good for me .

I saw that someones have tried mestinon with good results .please keep us update of the effects of cholin related medications .


Thank you very much
« Last Edit: June 18, 2018, 03:50:09 PM by emirnazim »
symptoms:extreme faique-over sleeping-High Blood Pressure-extreme irritability esp day two of O-poor memory and concentration-slow in(going-eating-reaction-driving-task doing)-week muscle-Mood changing-feel better in second O-high saliva-tired and asthma after heavy action or taking hot shower

Nas

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Quote
Irritability and change in sound or voice of me is the biggest ana noticable symptoms after O

When I tried to orgasm with Mestenon, these were my biggest symptoms and add to that growing difficulty in speaking.
« Last Edit: June 18, 2018, 04:12:05 PM by Nas »

demografx

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...mestinon really is working to me ...


Thank you for reporting, emirnazim!

Do you know if this is Rx only (prescription)...or over-the-counter?

Thanks!
Demo
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

emirnazim

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Hello demografx

What do you mean by over-the -counter

As you know , i m not native english speaker . But if you mean if this is a legal medication , i will say , yes in my country , every body can go to drug store and buy even one box of 150 of that without having a prescription from any doctor . But on the other hand doctors belive that we should take it with prescription . And i agree with that we should be aware of all effects and side effects of that in order to having a healthy treatment . I deeply do not suggest this medication for anyone here .but if anyone is worried about it , he can do it under the control of professional doctors . We should know about all the possible dangers from taking any medication . But i should say that im not a usa or european progressed citizen . I really do know that my country s doctors do not care about life and health .they are o the opinion like this : the more patient ...the more money .
For example one can have a not serious inflammation but doctors may request a ct scann test  >:(. You will find that doctor and ct scanner center manager is good friends  ;D. And they have a not appear relationship beside theire carrier . So in this situation , i suppose that getting the information through the internet may be is the healthiest way than taking tons of x-rays  .but finally i believe that the nature the world the body is working only under the rules .we call it Facts . I think the truth is one.not more . Its possible from my point of view that one can be more near the truth than professionals .the nature do not know and care about the person who prescirebed this medication it is only care about what medication injected through the body . Sorry about long text .i only wanted carry my senses . Finally these are my believes .not suggestion or encouraging others to do some things.  :)
symptoms:extreme faique-over sleeping-High Blood Pressure-extreme irritability esp day two of O-poor memory and concentration-slow in(going-eating-reaction-driving-task doing)-week muscle-Mood changing-feel better in second O-high saliva-tired and asthma after heavy action or taking hot shower

demografx

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Thank you, emirnazim!

over-the-counter means that a doctor’s prescription is not necessary.


« Last Edit: June 19, 2018, 12:55:04 AM by demografx »
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

emirnazim

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Thank you for your reply Demografi

Would you please tell me if is it over-counter in your country too ??
symptoms:extreme faique-over sleeping-High Blood Pressure-extreme irritability esp day two of O-poor memory and concentration-slow in(going-eating-reaction-driving-task doing)-week muscle-Mood changing-feel better in second O-high saliva-tired and asthma after heavy action or taking hot shower

emirnazim

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Quote
Irritability and change in sound or voice of me is the biggest ana noticable symptoms after O

When I tried to orgasm with Mestenon, these were my biggest symptoms and add to that growing difficulty in speaking.

Hello nas .i have too this problem . Difficulty in finding words
symptoms:extreme faique-over sleeping-High Blood Pressure-extreme irritability esp day two of O-poor memory and concentration-slow in(going-eating-reaction-driving-task doing)-week muscle-Mood changing-feel better in second O-high saliva-tired and asthma after heavy action or taking hot shower

Quantum

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Thank you for your reply Demografi

Would you please tell me if is it over-counter in your country too ??

Hi emirnazim,

Mestinon is a prescription only drug, here, in North America, and is usually given for myasthena gravis.  It is a acetylcholinesterase inhibitor.

The most readily available and well-known natural product that is an acetylcholinesterase inhibitor is huperzine A.

Acetylcholinesterase inhibitors raise the level of acetylcholine by inhibiting the enzyme that is responsible for acetylcholine elimination  ( this enzyme is named acetylcholinesterase).  So,
acetylcholinesterase inhibitors bring cholinergic support, as more acetylcholine is available at active receptors sites.
« Last Edit: June 19, 2018, 09:04:17 AM by Quantum »
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259