Author Topic: Dopamine documents  (Read 1321 times)


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Dopamine documents
« on: January 06, 2017, 12:05:44 PM »
I will post here some documents about dopamine. I suspect dopamine to be an important element in Pois symptoms.

1/ What is dopamine ?
(very basic)

Dopamine is a neurotransmitter.
Nervous system works by 2 ways :
- "electric wires" (dendrites and axons)
- chemical messangers to pass "bridges" (synapses).
These messangers are called neurotransmitters.

There are many neurotransmitters. Some of them are excitative (like dopamine) and some others sedative depending if they increase or decrease nervous system acitivity.

2/ Dopamine linked to pois ?

Since the start dopamine has be suspected to be linked to Pois symptoms like mental confusion or muscular weakness.

Orgasm : during orgasm, lot of neurotransmitters and hormones are released, like dopamine.

Ejaculation : human semen is rich in catecholamines (dopamine-like molecule) .

=> We suspect dopamine levels to have abnormal fluctuations after ejaculation !

3/ Let's compare Pois cognitive symptoms to symptoms of low dopamine after specific anti-dopamine drug

from : Subjective Experiences During Dopamine Depletion (2005)

After 7 hours, Mr. A felt more distance between himself and his environment. Stimuli had less impact; visual and audible stimuli were less sharp. He experienced a loss of motivation and tiredness. After 18 hours, he had difficulty waking up and increasing tiredness; environmental stimuli seemed dull. He had less fluency of speech. After 20 hours, he felt confused. He felt tense before his appointment and had an urge to check his watch in an obsessive way.
After 24 hours, Mr. A had inner restlessness, flight of ideas; his ideas seemed inflicted, and he could not remember them. He felt a loss of control over his ideas. After 28 hours, he felt ashamed, frightened, anxious, and depressed. He was afraid that the situation would continue. At that time, blepharospasm, mask face, and tremor were noted. After 30 hours, he was tired and slept 11 hours. After 42 hours, he had poor concentration. In the next hours, he returned to normal.
The striatal-to-nonspecific binding ratio was 27% higher after Mr. A took AMPT compared to the baseline situation, indicating severe acute dopamine depletion (1).

3/ Dopamine and restless legs syndrome

A lack of dopamine is linked to restless legs syndrome :

The impressive relief from restless legs syndrome (RLS) symptoms provided by levodopa treatment indicates RLS is caused by a dopaminergic abnormality.

Some of us complain of restless legs syndrome after ejaculation. And maybe some symptoms like itchings finger tips pain ...etc could be explained by dopamine.

4/ 50% of the dopamine is released in the gut :

More than 90% of the body's serotonin lies in the gut, as well as about 50% of the body's dopamine, which is currently being studied to further our understanding of its utility in the brain.

Some of us complain about intestine problems after ejaculation.

[I have very very few time to write for the moment. I will update this topic very slowly ]
« Last Edit: January 13, 2017, 03:43:14 AM by b_jim »
Taurine = Anti-Pois


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Re: Dopamine documents
« Reply #1 on: January 14, 2017, 02:42:39 AM »

Excellent thread, b_jim!
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.


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Re: Dopamine documents
« Reply #2 on: June 17, 2018, 03:43:22 AM »
Excellent post. It's a shame that he neglected here and did not continue to discuss dopamine issue this is one of the reasons of pois


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Re: Dopamine documents
« Reply #3 on: June 17, 2018, 02:53:57 PM »
Yes, interesting. In [1] it is noted that niacin helps break down dopamine (by increasing the activity of COMT). I'm wondering if that could be the reason that niacin is effective for a lot of people here?

« Last Edit: June 17, 2018, 02:57:23 PM by dizzy »
POIS symptoms: red eyes, ear-pain, anxiety, speech problems, pale/ugly skin, stiff neck, double chin, tinnitus, light sensitivity. POIS even after stimulation without O.