Author Topic: Post Orgasmic Illness Syndrome "POIS": Case report (2011 paper)  (Read 15957 times)

emi_b

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Searching the Internet I have found this.

Name: Post Orgasmic Illness Syndrome "POIS": Case report
Authors:
Abdalla M Attia*, Magda H Al-Ziny, Hossam A Yasien
*Corresponding author: Andrology Unit, Minoufiya University, Shibin El Kom, Eygpt


Article link


Presented at
20th World Congress for Sexual Health 2011, 128

Background/Purpose: Post Orgasmic Illness Syndrome (POIS) was first reported and named by Waldinger & Schweitzer 2002. POIS is a newly described syndrome which seems to be old and more common than one would expect; however, it hasn’t been studied meticulously and hence many cases are still misdiagnosed.

Up until now, PIOS has been described mainly as a male orgasmic disorder, as most (> 97%) of the reported cases have been diagnosed in male subjects. Its manifestations start within seconds after orgasm and may continue for 4-7 days. These manifestations differ in their severity but, in most cases they are severe enough to make patients abstain from the sexual activities; especially ejaculation and orgasm. They are not uniform for each patient and can be grouped based on having a specific cluster of symptoms.

Currently, there is no effective treatment for POIS. Strong analgesics taken one hour pre-coital as; non steroidal anti-inflammatory drugs and tramadol HCl as well as selective serotonin re-uptake inhibitors may help some patients but in most cases they are of little or no benefit.

Main conclusion: Much more attention to this syndrome is needed to avoid its misdiagnosis, find an exact etiopathology and an effective line of treatment. Its association with different allergic reactions is worth considering in further investigations and evaluation of the syndrome.

Funding/Competing Interests: No relevant conflicts of interest declared.

Please note that most posters on this site present work that is preliminary in nature and has not been peer reviewed.

« Last Edit: November 09, 2012, 08:35:47 AM by emi_b »
I have cognitive, psychological and physical symptoms.
I am apologizing for my English if it is unclear.

emi_b

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Re: Post Orgasmic Illness Syndrome "POIS": Case report (2011 paper)
« Reply #1 on: August 09, 2011, 02:08:03 AM »
Hello all,

What do you think about the above article? It seem it was presented at 20th World Congress for Sexual Health (held in June 12-16 2011, Glasgow, UK).

It is a poster. You can get the PDF of it by following the link on that site.
It looks it is a very interesting article. It presents a case of a men with POIS, and also tryies to summarise the sugested explanations for POIS, although it seems it is not aware of the latest two article of Dr. Waldinger.
It also proves that more doctors are interested in POIS. At least one of the authors works in Egypt.

Any thoughts about it?
I have cognitive, psychological and physical symptoms.
I am apologizing for my English if it is unclear.

Daveman

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Re: Post Orgasmic Illness Syndrome "POIS": Case report (2011 paper)
« Reply #2 on: August 09, 2011, 08:07:26 AM »
Thank you emi,

Yes, as you say, I hadn't really noticed that they hadn't seen Dr. Waldiner's 2011 papers. That's a good indication that even without those papers they lend importance to POIS as a real and worthy malady.

The World Congress for Sexual Health is an important exposition for POIS, and I'm sure in subsequent years we will be receiving more attention there. At some point, the results of our research at NORD will be published there.

WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

emi_b

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Re: Post Orgasmic Illness Syndrome "POIS": Case report (2011 paper)
« Reply #3 on: August 15, 2011, 12:55:21 PM »

You are doing a great job emailing them Cornelius, thank you for both emails. Let's hope we will receive some response.
I have cognitive, psychological and physical symptoms.
I am apologizing for my English if it is unclear.

Daveman

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Re: Post Orgasmic Illness Syndrome "POIS": Case report (2011 paper)
« Reply #4 on: August 15, 2011, 01:01:30 PM »
Thanks seconded.

This positive action is much appreciated. Part of all of this is getting up off the chairs (even if it's in front of the computer) and doing stuff to move our goals.

Thanks again, both of you!

WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

demografx

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Re: Post Orgasmic Illness Syndrome "POIS": Case report (2011 paper)
« Reply #5 on: September 08, 2011, 08:30:34 PM »

Did I ever mention that I get really impulsive when I'm in the hole? ;)

I just got a reply from Drs Attia and Yasien looking for a detailed case history. I'm going to write one up, and send it on to them.



Cornelius, this is teriffic! Please share as much as you can about this.
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

emi_b

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Re: Post Orgasmic Illness Syndrome "POIS": Case report (2011 paper)
« Reply #6 on: September 23, 2011, 08:15:16 AM »
Thank you demografx for posting it on the welcome page.
I have cognitive, psychological and physical symptoms.
I am apologizing for my English if it is unclear.

demografx

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Re: Post Orgasmic Illness Syndrome "POIS": Case report (2011 paper)
« Reply #7 on: January 15, 2013, 01:23:43 PM »
Thank you for finding and presenting to us this body of work, emi_b!
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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« Last Edit: January 15, 2013, 01:37:53 PM by demografx »
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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Re: Post Orgasmic Illness Syndrome "POIS": Case report (2011 paper)
« Reply #10 on: June 14, 2013, 11:00:55 AM »
[Posted by new forum member, "yasienhossam", representing medical researchers who sign this posted letter. Posted Letter addressed to Dr. Marcel Waldinger]

"Dear Prof Waldinger,

It has given us great honor when the editors of F1000 Research had told us that you will be one of the reviewers of our paper but we were astonished when we read your response which  said that you refused  our work that was accepted (with reservation) by the other 3 referees.  We think and feel that it was not fair enough.
 Actually we respect your own opinion but we are surprised!; how it comes to reject a case report of POIS (the rare disease) and say that you encourage publication in that topic?!. Is it related to  what you think that; the idea of atopy may be a precipitating factor for POIS  is yours and not ours ?!.  We think that this is not true. This is because we discovered our case by the end of 2009 and at that time you have only one publication in 2002- in which you didn't refer at all to atopy. We have found that our patient is atopic and in addition to the cognitive  and body pains he feels post orgasmic; his atopy flares  up  eye irritation with severe body itching. By December 2009 and after preparing the report and before its publication we sent you 3 e-mails with about one week intervals,  by the full length paper to ask you your experience as the only reporter of this syndrome - at that time -  but sadly enough we didn't receive any reply.  Please, return back to your archive. Moreover;  in 2010; we shared the ISSM forum by this case report  also before you mention at all any relation of POIS to atopy -  you mentioned it only in your publication at 2011 -  and many of our colleagues who are ISSM members  shared by comments and discussion ; we remember that one of them was Prof. David Goldmeier. Please go back to the ISSM Forum 2010. This case report was presented  as a poster in the 20th World Congress for Sexual Health, held in June 12- 16, 2011, Glasgow, UK  , and published in its  proceedings . For the before mentioned reasons we think that; it is ours and not yours that; atopy may be a precipitating factor for POIS and we must ask about and check for it in any of POIS cases.
Our Dear Dr  Waldinger, in your reply one of the reasons for which you refused our case report -as you stated - is that we mentioned that; NSAIDs, tramadol and SSRIs may help and you didn't find any response to these drugs. We want to remind you that this is not our findings  but the references mentioned and our patient didn?t get any benefit from trying these drugs;  please you can read our case report again !.
What we feel very important and we want to discuss is the skin prick test as a diagnostic test for allergy. Do you think that it is a reliable one in this regard?  is it  enough to reach the final conclusion that POIS patients are allergic to their own semen and that this is the cause of POIS?. Basically; we know -  and it is scientifically proved -  that this test  has many false positive and negative results. Moreover; we as andrologists ; knew - and it is scientifically proved as well that; our semen is foreign for our body and our  immune system.  Immunologic tolerance to it  is not present as it formed only after our puberty where the immune system didn't identify it in utero. For this reason our God totally separated it from our immune system by what is well known now as the very competent Blood  Testis barrier that is formed by the highly efficient Sertoli Sertoli cell junctional complex.  It is not - as you mentioned on you tube - a hypothetical membrane. Only in certain known pathologic conditions this barrier may be broken. If occurred we form auto-antibodies against our semen. So; when we inject our own semen intradermaly we will react positively to it  as it is a foreign antigen for us. Please try to apply this very simple prick test for you and your assistants using your own semen; mostly you will get a positive reaction without having POIS. Moreover; if we suppose that;  allergy to the patient's  own semen is the cause of POIS; it was mandatory to measure serum and seminal plasma anti-sperm antibodies; IgA, IgG and IgM, to do immuno bead and MAR testing and to report on the patient's seminogram changes as in such cases ? if this is true -  POIS patients will  be mostly infertile as well. So; as you depended only upon the unreliable  skin prick test  and for the afore mentioned scientific facts,  we  - and we think that we will be shared by anyone who is interested in andrology -    think that; your conclusion is not right and we can't scientifically accept  that the cause of POIS is allergy to own semen.  
Dear Prof, we are surprised; how it comes that; only from two patients ? without placebo control ? wants us to accept that; hyposensitization using the patient's own semen is the treatment of POIS!.  Although your last two papers are published in a highly respectable journal we are sorry to say that; this is not right from the scientific facts mentioned above and they are only two patients. We think that; any benefit  if any is not more than placebo.
 
Thanks,   
Prof. Dr Abdalla attia & Dr  Hossam Yasien
Andrology Unit,
Faculty of Medicine,
Minoufiya University,
Egypt   "

 = = = = = = = = = = = = = = = = = = = = = = = = =

From Stef:

"yasienhossam, thank you for your excellent questioning!

I hope Waldinger will respond.

Best regards,
Demo

ps - contact info

Prof. dr. Marcel D. Waldinger
dr.m.d.waldinger@gmail.com  "




From "Stef/nordnurse"

"Dear Drs. Attia and Yasein,

I was just advised by demografx of your post.

Please apply for the POIS grant!!!  We'll give you an extension on the deadline.

Here's a link to the application:   http://tinyurl.com/bwhbn5k

FYI, we did send Dr. Attia the POIS RFP when it was first posted, because we had seen Dr. Attia's poster presentation from a conference that took place about one or two years ago.  Perhaps we had an incorrect email address for Dr. Attia.  "

Stefanie Putkowski, RN
NORD Research Program Administrator
research@rarediseases.org

« Last Edit: March 23, 2014, 10:36:17 PM by demografx »
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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Re: Post Orgasmic Illness Syndrome "POIS": Case report (2011 paper)
« Reply #11 on: June 14, 2013, 11:19:46 AM »
This is the article that was NOT approved by Waldinger, according to the letter from Egypt:
http://f1000research.com/articles/2-113/v1

« Last Edit: March 23, 2014, 10:34:54 PM by demografx »
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.