Author Topic: SILODOSIN  (Read 4531 times)

Vincent M

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SILODOSIN
« on: June 06, 2013, 10:41:08 PM »
HERE IS THE PLACE TO POST REFERENCES TO SCIENTIFIC ARTICLES/PAPERS ABOUT SILODOSIN
« Last Edit: June 06, 2013, 10:44:39 PM by Vincent M »
Taking ginger tea, no wheat, fenugreek+green tea/garlic, saw palmetto, niacin, boswellia, huperzine, B complex and nutmeg. See my treatment summary post for more info: http://poiscenter.com/forums/index.php?topic=81.msg3513#msg3513

Vincent M

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Re: SILODOSIN
« Reply #1 on: June 06, 2013, 10:42:14 PM »
J Sex Med. 2008 Sep;5(9):2185-90. doi: 10.1111/j.1743-6109.2008.00779.x. Epub 2007 Apr 9.

Inhibition of Seminal emission is the main cause of anejaculation induced by a new highly selective alpha1A-blocker in normal volunteers.

Kobayashi K, Masumori N, Hisasue S, Kato R, Hashimoto K, Itoh N, Tsukamoto T.
Source
Sapporo Medical University School of Medicine, Sapporo, Japan. kou@sapmed.ac.jp

Abstract

INTRODUCTION:
Recent studies have highlighted the influence of alpha1-adrenoceptor antagonists on ejaculatory function.
AIM:
We evaluated the effect of a new, highly selective alpha1A-blocker, silodosin, on ejaculatory function of normal volunteers.
METHODS:
The study included 15 healthy male urologists who voluntarily participated in the study. They took 4 mg of silodosin or a placebo twice daily for 3 days in a randomized, double-blind crossover design.
MAIN OUTCOME MEASURES:
We investigated the ejaculatory volume, sperm count in urine after ejaculation, and fructose concentration in seminal plasma before and after administration of the agents.
RESULTS:
All volunteers on silodosin had a complete lack of ejaculation. Three days after completion of silodosin, the mean ejaculatory volume recovered to the baseline level. There was no sperm in urine after ejaculation under silodosin administration in any volunteer.
CONCLUSIONS:
All volunteers on silodosin had anejaculation and did not show post-ejaculate sperm in their urine. The mechanism of ejaculatory dysfunction caused by silodosin is a loss of seminal emission.

http://www.ncbi.nlm.nih.gov/pubmed/18399947
Taking ginger tea, no wheat, fenugreek+green tea/garlic, saw palmetto, niacin, boswellia, huperzine, B complex and nutmeg. See my treatment summary post for more info: http://poiscenter.com/forums/index.php?topic=81.msg3513#msg3513

demografx

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Re: SILODOSIN
« Reply #2 on: June 06, 2013, 10:53:10 PM »
Historical NSF posts re Silodosin:
http://tinyurl.com/n543ox5
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.