Yeah, I too have been getting desens and am pretty far along in my treatment -- I should be at 1:10 in about 2 weeks. My body doesn't seem to have responded especially well to the process; unlike many of the other desens patients, I really only reacted to the shots upon first beginning them (at 1:1500, i believe), and even then the reactions were pretty mild (I never underwent full-blown POIS as a result of my shots). Despite this, though, i've seen a marked change in my POIS. While I still get symptoms post-O, they're reduced by upwards of 50% (and maybe as much as 60-65%) and are far far more bearable. In fact, the treatment has made O-ing without niacin completely tolerable -- although it's something I still try hard to avoid. As for the duration of my symptoms, i'm not sure whether or not it's been reduced, as I only O twice a week and use Celebrex immediately afterwards to eliminate any remaining symptoms. But I can say for sure that desens IS working.