Post Orgasmic Illness Syndrome (P.O.I.S.)

POIS Cause/Treatment Discussions => Investigation Areas => Topic started by: Muon on March 28, 2018, 06:13:03 PM

Title: Parameter input from members
Post by: Muon on March 28, 2018, 06:13:03 PM
I'm interested in the parameters poiscenter members would choose if they had to pick some from this lab:

http://www.imd-berlin.de/labor.html

Go through the catalog on the right side depicted by the alphabet. What do YOU want to see me get tested on? Make a list and show it. This is not much of a discussion thread on my part so I won't argue with the choice you made.
Do you want me to test these before and/or after an orgasm and after what time period. Those markers with ''nur im Rahmen von klinischen Studien'' are too expensive and is no option. Use the original german language page because the translated versions of that site may show incomplete lists (or switch between them).

Use the following sites for finding interesting papers/info about the parameter in question:
(Type in the parameter and a symptom for example and read some abstracts)

https://scholar.google.com

https://www.ncbi.nlm.nih.gov/pubmed/

https://en.wikipedia.org/wiki/Main_Page

Even if you rarely post on this forum input would be appreciated (forum lurkers included).
Title: Re: Parameter input from members
Post by: nanna1 on March 29, 2018, 11:49:50 PM
Hi Muon,

Some of these might be good test to get:

Granulocyte colony stimulating factor (GM-CSF), RANTES and IP-10 are chemokines (cytokines) that attract T cells to the site of an activated infection. (https://academic.oup.com/jid/article/186/Supplement_2/S171/2191269#89857105) GM-CSF, RANTES and IL-8 are released whenever JNK (herpes activating gene) is activated. (immediately before and after)
NMDA-Rezeptor-AAk and AMPA receptor AAk can help determine if there is Autoimmune encephalitis in the brain. (https://en.wikipedia.org/wiki/Autoimmune_encephalitis#Post_herpes_simplex_NMDA_antibody_encephalitis)
Progesterone is the major anti-inflammatory hormone.
MTHFR genotyping might be useful since herpes viruses require methylation to stay dormant.
Kynurenine is an indirect measure of PGE2 production (and vitamin B6 deficiency). IDO expression is controlled by COX-2 (AA/COX-2/PGE2/IFN-g/IDO). (immediately before and after)
Title: Re: Parameter input from members
Post by: ThisType on March 31, 2018, 09:46:22 PM
I don't know the symptoms you're seeing but from my perspective (cluster 1 symptoms), I would want to test choline and related metabolites as well as other b vitamin levels.  A number of people find relief with choline. I've listed a few thoughts here :
http://poiscenter.com/forums/index.php?topic=2486.0

Some of the tests run to determine choline levels are here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637180/#FN1
It is not clear to me if they are standard lab tests (I would be interested to know as well). The closest I could find on the lab site you list is not an exact match:
http://www.imd-berlin.de/en/subject-information/diagnostics-information/b-vitamine-messung-der-bioaktivitaet-mittels-id-vitr-test.html
Title: Re: Parameter input from members
Post by: Hopeoneday on April 03, 2018, 09:56:39 AM
Hi muon, did you tested for autoimune hepatitis?
Title: Re: Parameter input from members
Post by: Muon on April 03, 2018, 10:14:47 AM
No, but I have been tested for Hepatitis B, C and E because of elevated ALAT and ASAT. If you take a look at the auto anti-bodies page from my dropbox you will see a few of them being used in the diagnosis of autoimmune hepatitis but these are all negative.
Title: Re: Parameter input from members
Post by: Quantum on April 04, 2018, 04:04:04 PM
I didn't check for availability on the lab site you have linked to, Muon, but I would certainly see some of these being tested, because they are elevated in MCAS ( Mast Cells Activation Syndrome):

tryptase,
N-methyl histamine,
prostaglandin D2 or 11-beta- prostaglandin F2 alpha,
leukotriene E4

Also,  pro-inflammatory cytokines level would be interesting to test.

As noted by Romies in another thread, it is a problem that brain concentrations cannot be tested, otherwise, I would be very, very interested in checking kynurenine concentrations in brain during POIS,   I would specifically like to know if quinolinic acid and kynurenic acid concentrations in the brain are up during POIS, since I believe they are responsible for the glutaminergic excitotoxicity , and respectively cognitive, and emotional symptoms, in POIS.
Title: Re: Parameter input from members
Post by: Hopeoneday on April 13, 2018, 03:50:15 PM
I advice to test if this is posible test at all.
Leky gut(gut permeability).
Food intolerances and alergy.
Hawy metal toxyticy.
And this https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712273/
Title: Re: Parameter input from members
Post by: Muon on July 08, 2018, 09:34:00 AM
I'm placing this here for the sake of overview, it's from a conversation between me and Bletzer via private mail. He said:
''A good marker to see if you're lectin sensitive is to check if you have high levels of adiponectin''

I advice to test if this is posible test at all.
Leky gut(gut permeability).
I did do a test where I had to swallow a liquid with indigestible molecules to see if there were 'holes' in the intestines. The result was negative. Can't remember what substance it was, I can't find the document.
Title: Re: Parameter input from members
Post by: Muon on July 09, 2018, 09:30:57 AM
Another suggestion:
''Hi Muon,

There is a urinary 5-HIAA test (random) which may be cheaper than the serum tests for serotonin. You may like to check it if it is indeed cheaper in your country.

I think this test will indicate if we have enough production of serotonin. It's usually used to diagnose serotonin based tumours, i.e. the case of overproduction of serotonin.''
Title: Re: Parameter input from members
Post by: nanna1 on July 09, 2018, 08:30:40 PM
I'm placing this here for the sake of overview, it's from a conversation between me and Bletzer via private mail. He said:
''A good marker to see if you're lectin sensitive is to check if you have high levels of adiponectin''

I advice to test if this is posible test at all.
Leky gut(gut permeability).
I did do a test where I had to swallow a liquid with indigestible molecules to see if there were 'holes' in the intestines. The result was negative. Can't remember what substance it was, I can't find the document.
Hi Muon,
Was the liquid you swallowed lactulose and mannitol dissolved in water (https://www.gdx.net/product/intestinal-permeability-assessment-urine)?
Title: Re: Parameter input from members
Post by: Muon on July 10, 2018, 08:27:16 AM
Was the liquid you swallowed lactulose and mannitol dissolved in water (https://www.gdx.net/product/intestinal-permeability-assessment-urine)?
Yes